Evaluation of interactions of silibinin with the proteins ALS3 and SAP5 against Candida albicans

Autores

  • Cecília Rocha da Silva School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules
  • Francisca Lariza Damacieira Moura Christus University Center (UNICHRISTUS)
  • André Luis Almeida Alves Filho Christus University Center (UNICHRISTUS)
  • Rosana de Sousa Campos Christus University Center (UNICHRISTUS)
  • Vitória Pessoa de Farias Cabral School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules
  • Lívia Gurgel do Amaral Valente Sá School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules
  • Anderson Ramos da Silva Department of Surfactants and Nanobiotechnology,
  • Jacilene Silva Department of Chemistry, Group for Theoretical Chemistry and Electrochemistry
  • Akenaton Onassis Cardoso Viana Gomes Christus University Center
  • Letícia Bernardo Barbosa Christus University Center http://orcid.org/0000-0003-0276-711X
  • Hélcio Silva dos Santos Department of Chemistry, Group for Theoretical Chemistry and Electrochemistry (GQTE),
  • Emmanuel Silva Marinho Department of Chemistry, Group for Theoretical Chemistry and Electrochemistry (GQTE),
  • Bruno Coelho Cavalcanti Federal University of Ceará
  • Hélio Vitoriano Nobre Júnior Federal University of Ceará
  • João Batista De Andrade Neto School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN)

DOI:

https://doi.org/10.12662/2317-3076jhbs.v10i1.4239.p1-6.2022

Resumo

Objective: to evaluate the molecular interaction of silibinin with the targets ALS3 and SAP5. Methodology: Molecular docking protocols were conducted to analyze the binding interaction of silibinin with ALS3 and SAP5. Results: Eleven interactions of ALS3 with silibinin and four with fluconazole were found, while six interactions were observed of SAP5 with silibinin and four with fluconazole. Conclusion: Molecular docking between silibinin and ALS3 identified important interactions, but no significant interactions were observed with SAP5, even though silibinin can exhibit affinity and interactions with other SAP5 sites.

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Publicado

2022-06-01

Como Citar

1.
da Silva CR, Damacieira Moura FL, Almeida Alves Filho AL, Campos R de S, Cabral VP de F, Valente Sá LG do A, et al. Evaluation of interactions of silibinin with the proteins ALS3 and SAP5 against Candida albicans. J Health Biol Sci. [Internet]. 1º de junho de 2022 [citado 23º de dezembro de 2024];10(1):1-6. Disponível em: https://unichristus.emnuvens.com.br/jhbs/article/view/4239

Edição

v. 10 n. 1 (2022): Journal of Health and Biological Sciences

Seção

Artigos Originais

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Este artigo está licenciada sob uma licença Creative Commons - Atribuição-Não Comercial- Sem Derivações 4.0 Internacional