EVALUATION OF INTERACTIONS OF SILIBININ WITH THE PROTEINS ALS3 AND SAP5 AGAINST Candida albicans

Authors

  • Cecília Rocha da Silva School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil. Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
  • Francisca Lariza Damacieira Moura Christus University Center (UNICHRISTUS), Fortaleza, Ceará, Brazil
  • André Luis Almeida Alves Filho Christus University Center (UNICHRISTUS), Fortaleza, Ceará, Brazil
  • Rosana de Sousa Campos Christus University Center (UNICHRISTUS), Fortaleza, Ceará, Brazil
  • Vitória Pessoa de Farias Cabral School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil. Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
  • Lívia Gurgel do Amaral Valente Sá School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil. Christus University Center (UNICHRISTUS), Fortaleza, Ceará, Brazil Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
  • Anderson Ramos da Silva Department of Surfactants and Nanobiotechnology, IQAC-CSIC, Barcelona, Spain.
  • Jacilene Silva Department of Chemistry, Group for Theoretical Chemistry and Electrochemistry (GQTE), State University of Ceará, , Ceará, Brazil.
  • Akenaton Onassis Cardoso Viana Gomes Christus University Center (UNICHRISTUS), Fortaleza, Ceará, Brazil
  • Letícia Bernardo Barbosa Christus University Center http://orcid.org/0000-0003-0276-711X
  • Hélcio Silva dos Santos Department of Chemistry, Group for Theoretical Chemistry and Electrochemistry (GQTE), State University of Ceará, , Ceará, Brazil.
  • Emmanuel Silva Marinho Department of Chemistry, Group for Theoretical Chemistry and Electrochemistry (GQTE), State University of Ceará, , Ceará, Brazil.
  • Bruno Coelho Cavalcanti Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
  • Hélio Vitoriano Nobre Júnior School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil. Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
  • João Batista De Andrade Neto School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil. Christus University Center (UNICHRISTUS), Fortaleza, Ceará, Brazil Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.

DOI:

https://doi.org/10.12662/2317-3076jhbs.v10i1.4239.p1-6.2022

Abstract

Introduction: Fungi of the genus Candida spp. are responsible for most invasive fungal infections. The number of clinical isolates resistant to antifungals like fluconazole is growing. In this context, herbal medicines are being studied for use alone or in combination with other drugs as alternatives to treat these infections. Among them is silibinin, a silymarin compound extracted from Silybum marianum, which has a wide range of therapeutic properties, such as anti-inflammatory, anti-fibrotic, hepatoprotective and antioxidant, as well as synergism with some antibiotics. Objective: To evaluate the molecular interaction of silibinin with the targets ALS3 and SAP5. Methodology: Molecular docking protocols were conducted to analyze the binding interaction of silibinin with ALS3 and SAP5. Results: Eleven interactions of ALS3 with silibinin and four with fluconazole were found, while six interactions were observed of SAP5 with silibinin and four with fluconazole. Conclusion: Molecular docking between silibinin and ALS3 identified important interactions, but no significant interactions were observed with SAP5, even though silibinin can exhibit affinity and interactions with other SAP5 sites.

 

Keywords: Silibinin, Fungal Infection, Candida spp., Molecular Docking, Adhesion Proteins.

Downloads

Download data is not yet available.

Downloads

Published

2022-06-01

How to Cite

1.
da Silva CR, Damacieira Moura FL, Almeida Alves Filho AL, Campos R de S, Cabral VP de F, Valente Sá LG do A, et al. EVALUATION OF INTERACTIONS OF SILIBININ WITH THE PROTEINS ALS3 AND SAP5 AGAINST Candida albicans. J Health Biol Sci. [Internet]. 2022 Jun. 1 [cited 2024 Dec. 23];10(1):1-6. Available from: https://unichristus.emnuvens.com.br/jhbs/article/view/4239

Issue

Vol. 10 No. 1 (2022): Journal of Health and Biological Sciences

Section

Original articles

License

Authors who publish with this journal agree to the following terms:


a) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

b) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

c) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).


Declaration

Transfer of Copyright


The author hereby declare that the article entitled "TITLE OF THE ARTICLE" approved for publication in the Journal of Health & Biological Sciences is an original work that has not been published or is being considered for publication elsewhere, that is in print or electronic.
The author's manuscript quoted above also states (m):

  1. I certify that I have participated sufficiently in the work to take public responsibility for the content.
  2. I declare that the use of any trademark or copyright in the manuscript has been credited to its owner or permission to use the name was given, if necessary.
  3. I declare that I agree that the copyright for the article referenced above will become the exclusive property of the Journal of Health & Biological Sciences - JHBS, any form of reproduction, in whole or in part, in any form or means of disclosure, printed or electronic, without the prior authorization is required, and, if obtained, I include my thanks to the Journal of Health & Biological Sciences - JHBS.
  4. The original submission to the Journal of Health and Biological Sciences (JHBS) imply transfer by authors, printed and digital publishing rights.

Note: All persons listed as authors must sign this statement and signed statements will not be accepted by others.
The original statement shall be signed, dated and sent to the address below or by email:
JOURNAL OF BIOLOGICAL SCIENCES & HEALTH
Councilman Paul Street Mamede, 130 - 5th floor - Neighborhood: Coco.
Fortaleza - CE
CEP 60192-350
Phone: (85) 3265-8109, Ext: 8109
e-mail: @ secretaria.jhbs fchristus.edu.br