Parameters pharmacokinetic, pharmacodynamic and toxicity of hydroxychloroquine

a review

Abstract

Introduction: Tto verify the toxicity of the use of hydroxychloroquine medications in patients. Methods: it is an integrative literature review with a documentary evaluation and descriptive approach conducted in the electronic databases LILACS, SCIELO, and MEDLINE-PUBMED, using different combinations of descriptors, published between 2015 and 2023 in English, Spanish, and Portuguese. Results: this study reviewed 117 scientific articles, with 67 of them conducted in the United States. Besides that, 2020 had a 21.2% increase in publications compared to 2015. It was observed that 44.07% of the injuries caused by hydroxychloroquine use were ophthalmic, 35.5% were cardiac, 14.4% were dermatological, and the remaining percentages accounted for other types of injuries. Conclusion: therefore, the obtained results confirm the toxicity of hydroxychloroquine in the use of adjacent treatments.