Mutagenic Evaluation of Fluoxetine and Fluoxetine-Galactomannan Complex Through the Analysis of Chromosomal Aberrations in Human Peripheral Leukocytes and Salmonella typhimurium/Microssome Assay
DOI:
https://doi.org/10.12662/2317-3076jhbs.v10i1.4461.p1-6.2022Keywords:
Fluoxetine, Galactomannan, Mutagenicity, Chromosomal aberrations, Salmonella typhimurium /microsome assayAbstract
Objectives: The purpose of this study was to evaluate the mutagenic potential of fluoxetine and fluoxetine-galactomannan. Methods: Chromosomal aberration test and Salmonella typhimurium/microsome mutagenicity assay. Results: The results showed that fluoxetine (250 μg/mL) can cause chromosomal breaks of treated leukocytes and increase the frequency of reversion of the tester strains of S. typhimurium / microsome assay only at the highest concentration (5 mg/mL), while fluoxetine encapsulated in galactomannan did not cause these changes (leukocytes and S. typhimuriums strains). Conclusion: In summary, fluoxetine showed a mutagenic effect detectable only at high concentrations in both eukaryotic and prokaryotic models. Furthermore, the fluoxetine/galactomannan complex, in this first moment, prevented the mutagenicity attributed to fluoxetine, emphasizing that the present encapsulation process can be an alternative in preventing these effects in vitro.
Downloads
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
a) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
b) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
c) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
Declaration
Transfer of Copyright
The author hereby declare that the article entitled "TITLE OF THE ARTICLE" approved for publication in the Journal of Health & Biological Sciences is an original work that has not been published or is being considered for publication elsewhere, that is in print or electronic.
The author's manuscript quoted above also states (m):
- I certify that I have participated sufficiently in the work to take public responsibility for the content.
- I declare that the use of any trademark or copyright in the manuscript has been credited to its owner or permission to use the name was given, if necessary.
- I declare that I agree that the copyright for the article referenced above will become the exclusive property of the Journal of Health & Biological Sciences - JHBS, any form of reproduction, in whole or in part, in any form or means of disclosure, printed or electronic, without the prior authorization is required, and, if obtained, I include my thanks to the Journal of Health & Biological Sciences - JHBS.
- The original submission to the Journal of Health and Biological Sciences (JHBS) imply transfer by authors, printed and digital publishing rights.
Note: All persons listed as authors must sign this statement and signed statements will not be accepted by others.
The original statement shall be signed, dated and sent to the address below or by email:
JOURNAL OF BIOLOGICAL SCIENCES & HEALTH
Councilman Paul Street Mamede, 130 - 5th floor - Neighborhood: Coco.
Fortaleza - CE
CEP 60192-350
Phone: (85) 3265-8109, Ext: 8109
e-mail: @ secretaria.jhbs fchristus.edu.br
